Oral Minoxidil

Oral finasteride is an FDA-approved prescription hair loss treatment, while oral minoxidil is considered an off-label prescription for hair loss. This means oral minoxidil is not FDA-approved for that particular use, but a provider can still prescribe it if they deem it safe and appropriate for the patient.

Oral minoxidil may be preferred by men who do not want to risk the known slight chance of sexual side effects from taking finasteride. Oral minoxidil and oral finasteride have different mechanisms of action to tackle hair loss. Your provider will recommend a treatment based on your medical history, lifestyle, and any particular treatment preferences or side effect aversions you may have.

Topical minoxidil is an FDA-approved hair loss treatment that does not require a prescription whereas oral minoxidil is considered an off-label prescription for hair loss and does require a prescription. “Off-label” means it’s not FDA-approved for that particular use, but can still be prescribed at the provider’s discretion.

Topical and oral minoxidil contain the same active ingredient. While there have not been clinical studies comparing their efficacy, there appear to be some benefits of using an oral treatment method vs. a topical treatment method, such as more precise dosing and better treatment adherence & consistency.

Some people may also benefit less from topical minoxidil due to lower levels of a specific enzyme in their hair follicles (follicular sulfotransferase). Oral minoxidil may be an effective alternative in this case, as the medication is absorbed systemically and is thought to be activated by the liver.

Some people may get results from topical minoxidil but still want to consider oral minoxidil due to negative experiences with the topical such as scalp irritation, treatment running down your neck before you can rub it in, or the hassle of applying treatment two times a day.

Using both topical minoxidil and oral minoxidil at the same time will not produce better results and therefore, is not recommended.

Oral minoxidil was originally studied for blood pressure, and the hair growth effects were unintentional. In clinical trials, patients who experienced hypertrichosis (“elongation, thickening, and enhanced pigmentation of body hair”) noticed it on the forehead and temples, between the eyebrows, or on the upper part of the cheeks within three to six weeks after beginning treatment. Hair growth on the scalp was observed at a later date.

Similar to topical minoxidil, oral minoxidil takes a few months to produce noticeable results to your crown and hairline. If you stop taking oral minoxidil, new hair growth will stop as well.

Oral minoxidil might not work for everyone or may only partially resolve the concern. If you aren’t getting the results you hoped for, you can always reach out to your provider to discuss treatment options.

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• Early results may be seen within a few months, but it could take longer to see the full effects
• You may experience shedding during the first few weeks of treatment. This is normal and shouldn’t cause you to worry. Extra shedding will resolve as the new hair grows in (usually in about a month)
• If you do not see improvement after 6 months of consistent use, you can message your provider to discuss adjusting your treatment plan

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The jury is still out on exactly how minoxidil works with regards to hair loss. While the exact mechanism is not completely understood, it’s thought to increase the length of the growth phase of hair follicles and increase the size of hair follicles, which is thought to promote hair regrowth and increased density.

Minoxidil is also thought to relax smooth muscle in blood vessel walls, causing them to widen and increase blood flow. This may be another way that minoxidil works to stop or slow hair loss and promote hair regrowth and increased hair thickness

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While there are any number of underlying causes for hair loss that affect women, the vast majority of cases can be attributed to one of two conditions. Sometimes these two conditions overlap with both of them contributing to an individual’s noticeable hair loss.

The most common cause is called female pattern hair loss (FPHL). It is a chronic, progressive hair loss that can start at any age and presents as progressive thinning of the hair, particularly at the top and front of the scalp. The cause is not entirely clear but is believed to be multifactorial, including possibly genetic predisposition and hormonal factors. The earlier treatment is begun the better likelihood of slowing progression and seeing regrowth.

The other common hair loss condition is called telogen effluvium (TE). The condition is characterized by an increase in the amount of shedding that one normally experiences. The condition represents the early release of hairs that are in the resting phase of the hair growth cycle. It’s typically brought on by some sort of trigger event. Most commonly this happens after childbirth with about 30-50% of postpartum women experiencing it. Other potential triggers include major life stressors, hospitalization, illness (e.g., COVID), surgery, and certain medications.

TE also has a specific chronic form that typically affects women 30-60 years of age. There is no identifiable trigger to the increased hair shedding for chronic TE. It can run a course over months and years with the shedding fluctuating in terms of severity. Even if it’s been going on for years there is no progressive change in density that is noticeable to an observer, but the individual affected may note decreased volume.

Good Life offers access to treatment for both of these hair loss conditions.

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Common side effects can include low blood pressure (hypotension) and swelling in the legs (edema), among others. Some people experience headaches, although those typically improve over time. Others may experience additional hair growth on the face or body (hypertrichosis). This is the most common side effect of taking oral minoxidil, though the complaint is more common among women than men and is also more common when taking over 5 mg per day.

Side effects of oral minoxidil may be more pronounced when the drug is prescribed at higher doses. For full safety information (including the boxed warning)

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Many patients find it easier to take a medication by mouth once a day vs. applying a topical treatment . A simpler routine can help to improve treatment adherence and consistency (in other words, it’s easier to make and keep a daily treatment habit), which supports better results.

While a patient’s preference is always taken into consideration, treatment recommendations will be primarily informed by the individual’s medical history along with the contraindications and potential side effects of oral minoxidil.

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